Preheat oven to 350ºF (177ºC). Spray a 9x13-inch baking dish with nonstick cooking spray; set aside.
Cook pasta (2 cups) in well-salted water, according to the package instructions, just until al dente.
Meanwhile, in a medium mixing bowl stir together all the rest of the ingredients, except the cheeses.
Drain the pasta. Return drained pasta immediately to the pot it was just cooked in. Fold in the cheddar (8 ounces), American cheese (8 ounces), and cream cheese (4 ounces) until evenly combined.
Pour the pasta and cheese mixture into the prepared 9x13-inch baking dish. Pour the whisked ingredients evenly over the pasta.
Bake in the preheated oven until bubbly, 40-45 minutes. Let stand for 10 minutes prior to serving.