Preheat oven to 350ºF (177ºC). Lightly butter an 8-inch pie plate or spray with nonstick cooking spray; set aside.
Add pumpkin puree (1 can), evaporated milk (1 can), room temperature butter (2 tablespoons), and eggs (2) to a blender and pulse until combined.
Add all remaining ingredients and mix on high for one minute.
Pour the batter into the prepared pie plate and bake until the center is set, or a toothpick (knife) inserted in the center of the pie comes out clean, about 50 to 55 minutes. Rotate a pie halfway through baking. Cool on a wire baking rack.
Notes
Room Temp: Make sure the butter and eggs are at room temperature for an evenly blended batter.
Make It Richer: For a richer custard, use half and half.
Avoid Overbaking: Check your pie at least 5-7 minutes before the pie is estimated to be done.
No Pumpkin Pie Spice: If you don’t have Pumpkin Pie Spice on hand, make your own: 4 tablespoons cinnamon, 4 teaspoons nutmeg, 1 teaspoon ginger, and 1 teaspoon cloves.
No Blender? Add all the ingredients in a mixing bowl, and using a handheld electric mixer, beat on medium speed for 2 minutes.
Make It Gluten Free: Just switch out regular Bisquick with gluten-free Bisquick mix and et, voilà! Your pie is gluten-free.
Diabetic Friendly: Swap Splenda for the sugar. Use the same amount. The substitution ratio is 1:1.