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This Chicken and Stuffing Casserole is the ultimate comfort food dinner — tender rotisserie chicken, broccoli, and a rich, creamy sour cream sauce topped with buttery Stove Top stuffing and baked until hot and bubbly. It’s hearty, family-friendly, and easy enough for even the busiest weeknights.
One of my favorite things about this chicken and stuffing casserole recipe is that it tastes like a cozy Sunday dinner but comes together with simple shortcut ingredients and just a few minutes of prep. The savory stuffing topping, creamy chicken filling, and flavorful seasonings make every bite completely irresistible.
If you love easy chicken casseroles, be sure to try my Million Dollar Chicken Casserole, White Chicken Enchiladas, Chicken Cordon Bleu Casserole, and Chicken Noodle Casserole.
✨ Before You Begin
✨ Drain the broccoli well. Excess moisture can thin the creamy sauce and make the stuffing topping soggy.
✨ Use rotisserie chicken. It’s the quickest option and adds plenty of savory flavor to the casserole.
✨ Prepare the stuffing first. Letting it rest while you mix the filling gives it time to absorb the liquid and develop better texture.
✨ Cut the chicken into bite-sized pieces. This makes the casserole easier to serve and ensures every bite gets plenty of chicken.
✨ Taste the filling before baking. Depending on the brand of soup and stuffing mix you use, you may want an extra pinch of salt or black pepper.
Chicken and Stuffing Casserole Ingredients + Key Notes
Stuffing Mix: I usually use Stove Top stuffing mix for convenience, though leftover homemade stuffing works beautifully too.
Broccoli: Use frozen broccoli that’s been completely thawed and well drained. Excess moisture can make the casserole watery and soften the stuffing topping.
Chicken: Rotisserie chicken adds incredible flavor and makes this recipe extra easy. You can also use any cooked chicken you have on hand. I prefer cubed chicken so you get a little chicken and broccoli in every bite.
Cream of Chicken Soup: Creates the rich, creamy base of the casserole. You can substitute cream of mushroom, cream of celery, or a combination of your favorite condensed soups.
Sour Cream: Adds richness and a slight tang that balances the savory flavors.
White Wine: Adds depth and enhances the overall flavor of the sauce. Chicken broth works well if you prefer not to cook with wine.
Lemon Juice: Brightens the sauce and balances the richness.
Worcestershire Sauce: Adds savory, slightly tangy depth that makes the filling taste more complex.
Thyme + Poultry Seasoning: These herbs give the casserole its cozy, comforting flavor and pair perfectly with the stuffing topping.
Salt + Black Pepper: Season to taste and adjust if needed before assembling the casserole.
🥣 How To Make Chicken and Stuffing Casserole
Prepare the stuffing. Make the stuffing according to the package directions, then set it aside while you prepare the filling.
Mix the creamy sauce. In a large bowl, stir together the cream of chicken soup, sour cream, white wine, lemon juice, Worcestershire sauce, thyme, poultry seasoning, salt, and black pepper until smooth.
Add the chicken and broccoli. Fold in the cooked chicken and drained broccoli until everything is evenly coated in the sauce. Transfer the mixture to a greased 9X13-inch baking dish.
Top and bake. Spread the prepared stuffing evenly over the casserole, then bake for 25-30 minutes or until hot, bubbly, and heated through.
Serve and enjoy. Let the casserole rest for a few minutes before serving, then dig into this creamy, comforting family favorite.
See the recipe card below for complete instructions.
⭐ Pro Tips
⭐ Drain the broccoli thoroughly. This is the most important step for preventing a watery casserole. After thawing, gently squeeze out any excess moisture with paper towels.
⭐ Use rotisserie chicken for the best flavor. The seasoning and tender texture add extra depth to the casserole while saving valuable prep time.
⭐ Don’t overbake. The chicken is already cooked, so you’re simply heating everything through. Overbaking can dry out the filling and stuffing topping.
⭐ Let it rest before serving. Allow the casserole to sit for 5-10 minutes after baking so the creamy filling can set up slightly and serve more neatly.
⭐ Customize the vegetables. Not a broccoli fan? Try frozen mixed vegetables, peas, green beans, or even sautéed mushrooms instead.
⭐ Make it extra cozy. For an even richer casserole, sprinkle 1 cup shredded cheddar cheese over the chicken mixture before adding the stuffing topping.
Storing + Reheating + Freezing + Make-Ahead
Storing: Store leftover Chicken and Stuffing Casserole in an airtight container in the refrigerator for up to 3 days.
Reheating: Reheat individual portions in the microwave until warmed through. For larger portions, cover the casserole with foil and warm in a 325°F oven until hot. If the stuffing topping seems dry, sprinkle a tablespoon or two of chicken broth over the top before reheating.
Freezing: I don’t recommend freezing this casserole. The sour cream-based sauce can separate after thawing, and the broccoli’s texture tends to become mushy. Since the recipe comes together so quickly, it’s best enjoyed fresh.
Make-Ahead: Assemble the casserole as directed, cover tightly, and refrigerate for up to 2 days before baking. For the best stuffing texture, I recommend preparing the chicken filling and storing it separately from the stuffing. When you’re ready to bake, prepare the stuffing, spread it over the casserole, and bake as directed. If baking directly from the refrigerator, you may need to add 5-10 minutes to the baking time.
What to Serve With Chicken and Stuffing Casserole
Fresh + Crisp Sides
Balance the rich, creamy casserole with a crisp side like 1905 Salad, Harvest Salad, Carrot Salad, or a simple House Salad with your favorite vinaigrette.
Cozy Vegetable Sides
If you’re feeding a crowd, add another vegetable side such as Southern Green Beans, Honey Glazed Carrots, or Creamed Peas.
Warm Breads
This casserole is delicious with Cheddar Biscuits, Cat Head Biscuits, Garlic and Herb Parker House Rolls, or a warm loaf of crusty bread for soaking up every bit of the creamy sauce.
Sweet Finishes
Finish dinner with a comforting dessert like Hersheys Chocolate Chip Cookies, Apple Crisp, Sugar Cream Pie, or Cherry Delight for an easy family-style meal.
This Chicken and Stuffing Casserole is hearty enough to stand on its own, but a fresh salad and warm bread turn it into the ultimate comfort food dinner.
Frequently Asked Questions
✦ Can I use rotisserie chicken?
Absolutely! Rotisserie chicken is my favorite shortcut for this recipe because it’s flavorful, tender, and saves a lot of prep time. You’ll need about 4 cups of shredded or cubed chicken.
✦ Can I make Chicken and Stuffing Casserole ahead of time?
Yes! You can assemble the casserole up to 2 days ahead and refrigerate it until you’re ready to bake. For the best texture, wait to add the stuffing topping until just before baking.
✦ Can I substitute cream of mushroom soup?
Yes. Cream of mushroom soup, cream of celery soup, or even a combination of condensed soups work well in place of cream of chicken soup.
✦ Can I make this without broccoli?
Of course. You can simply leave the broccoli out or replace it with peas, green beans, mixed vegetables, or sautéed mushrooms.
✦ Why does this recipe use sour cream?
Sour cream adds richness and creates the creamy texture that makes this casserole so comforting. It also adds a slight tang that balances the savory stuffing and chicken.
✦ What stuffing mix works best?
I usually use Stove Top Chicken Stuffing because it’s convenient and consistently delicious, but any seasoned stuffing mix or leftover homemade stuffing will work.
✦ Can I use leftover turkey instead of chicken?
Yes! This recipe is a great way to use leftover holiday turkey. Simply substitute an equal amount of cooked turkey for the chicken.
Still have questions? Leave them in the comments below and I’ll do my best to help! ♥
More Chicken Casserole Recipes
Chicken Divan – Tender chicken and broccoli baked in a rich, creamy sauce and topped with buttery breadcrumbs for a classic comfort food dinner.
Chicken Tater Tot Casserole – Crispy golden tater tots, savory chicken, bacon, and plenty of melted cheese make this family favorite impossible to resist.
Poppy Seed Chicken Casserole – A creamy chicken casserole topped with buttery cracker crumbs and poppy seeds for a nostalgic Southern favorite.
Chicken and Rice Casserole – A cozy, hearty casserole featuring tender chicken, fluffy rice, and a creamy sauce that’s perfect for busy nights.
Dorito Chicken Casserole – Layers of seasoned chicken, creamy sauce, cheese, and crunchy Doritos create a fun, flavor-packed dinner the whole family will request again and again.
Tried This Recipe?
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This Chicken and Stuffing Casserole is one of those easy comfort food dinners that never goes out of style. If you make it, I’d love to hear how it turned out!
Leave a star rating and comment below to let me know what you think. Did you stick with the broccoli, add cheese, or put your own spin on it? I always enjoy hearing how you make these recipes your own.
And don’t forget to follow me on Instagram @gonna_want_seconds for behind-the-scenes cooking, new recipe updates, and plenty of delicious inspiration.
Thanks for stopping by my kitchen today — happy cooking, friends! ❤️ Kathleen
Chicken And Stuffing Casserole
Ingredients
- 1 (6-ounce) package STOVE TOP Stuffing Mix for Chicken
- 2 (10-ounce) packages frozen chopped broccoli, thawed and drained
- 2 cans condensed cream of chicken soup
- 1 1/2 cups sour cream
- 1/2 cup white wine
- 1 tablespoon fresh lemon juice
- 2 teaspoons Worcestershire sauce
- 1/2 teaspoon dried thyme
- 1 teaspoon dried poultry seasoning
- 1/4 teaspoon salt
- 1/2 teaspoon black pepper
- 3 cups rotisserie chicken, cubed or shredded
Instructions
- Preheat oven to 350ºF (177ºC). Spray a 9X13-inch baking dish with nonstick cooking spray.
- Prepare stuffing (1 package) according to package directions using the ingredients per the package (I didn't list them in the ingredient list above). Set aside.
- In a large bowl, combine soup (2 cans), sour cream (1 1/2 cups), wine (1/2 cup), lemon juice (1 tablespoon), Worcestershire sauce (2 teaspoons), thyme (1/2 teaspoon), poultry seasoning (1 teaspoon), salt (1/4 teaspoon), and black pepper (1/2 teaspoon) and mix until combined. Gently mix in chicken (3 cups) and broccoli (2 packages) until all ingredients are evenly coated in the sauce. Pour mixture into prepared baking dish. Evenly top chicken mixture with prepared stuffing.
- Bake uncovered in preheated oven for 25-30 minutes or until casserole is heated through and bubbly.
Fans Also Made:
Notes
- Drain the broccoli thoroughly. This is the most important step for preventing a watery casserole. After thawing, gently squeeze out any excess moisture with paper towels.
- Use rotisserie chicken for the best flavor. The seasoning and tender texture add extra depth to the casserole while saving valuable prep time.
- Don’t overbake. The chicken is already cooked, so you’re simply heating everything through. Overbaking can dry out the filling and stuffing topping.
- Let it rest before serving. Allow the casserole to sit for 5-10 minutes after baking so the creamy filling can set up slightly and serve more neatly.
- Customize the vegetables. Not a broccoli fan? Try frozen mixed vegetables, peas, green beans, or even sautéed mushrooms instead.
- Make it extra cozy. For an even richer casserole, sprinkle 1 cup shredded cheddar cheese over the chicken mixture before adding the stuffing topping.
Do you cook the stuffing before you top the casserole or just mix it together per package?
Yes, in direction #2, prepare stuffing according to package directions 🙂
Looks delicious! We love stuffing- do you think we could use 2 boxes of stuffing and keep the rest the same?
Well, Jennifer, it sounds absolutely delicious. I’m crazy for stuffing too! I’m sorry I haven’t tried it this way so I can’t advise! If you try, please LMK how it turns out!!! Happy cooking 🙂
Had this casserole years ago at a friend’s ski house.Could not find the recipe ,I want say it had a ranch flavor but with a cornbread stove top.Could you use greek yogurt or butter milk in place of sour cream omit wine.just use lemon juice for acid?Also not one bit of this casserole was left.Yum and super easy
Add a salad, dessert ,a glass of wine good to go
Hi Gretchen! Yes, you can omit white from this recipe. Also, you can sub sour cream for Greek yogurt/buttermilk. For the yogurt, you can use the same amount as the sour cream. I haven’t tried the buttermilk yet so I can’t advise for this one. Hope this helps! 😀
Is it possible to leave out the sour cream?
Hi Jessi, yes but the sauce won’t be quite as thick or flavorful.
Oh my goodness, my mom used to make something just like this when I was a kid! (Except she added mushrooms to hers) Totally making this for a nostalgia trip this week!!
Enjoy, Sarah! ❤️?
Saved this for tomorrow!
Enjoy, May! Let us know how it turns out for you!❤️
I already have all the ingredients in the fridge, I tried it last night and it was awesome!
❤️❤️
Can I use fresh broccoli in place of frozen & should I cook it?
Hi, Irla! You can definitely use fresh broccoli 😀 just bake it together with the casserole as instructed. Hope this helps!
Can something else be substituted for the wine? Not a wine person.
Hi Sandy! Yes absolutely, chicken broth! <3